LIVER FIBROSIS AND METABOLIC CHANGES IN NON-ALCOHOLIC FATTY LIVER DISEASE: MODERN APPROACHES TO DIAGNOSTICS
Keywords:
Non-alcoholic fatty liver disease (NAFLD), liver fibrosis, FibroScan, microRNA-221, DEBQ questionnaire, liver enzymes, triglycerides, ALT/AST ratio.Abstract
This study is devoted to the assessment of metabolic changes and the degree of liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD), including steatosis of varying degrees. The study included 90 patients with NAFLD and 45 people in the control group.
Research methods: clinical and laboratory methods, ultrasound elastometry (FibroScan), DEBQ questionnaire to identify eating disorders, molecular genetic analysis of the expression level of microRNA-221.
References
Cherkashina E. A. Actual issues of diagnosis and treatment of non-alcoholic fatty liver disease. Medical advice. 2015; 34:67–71. (in Russ.)
Drapkina O., Ivashkin V. Prevalence and risk factors for non–alcogolic fatty liver disease in Russian Federation. International Liver Congress 2010. Abstract book. 2010: 138. (in Russ.)
European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease. Obesity Facts. 2016;9(2):65-90. DOI:10.1159/000443344
Jennison E, Patel J, Scorletti E, Byrne CD. Diagnosis and management of non-alcoholic fatty liver disease. Postgrad Med J. 2019;95(1124):314-22. DOI:10.1136/postgradmedj-2018-136316
Itskova E. A., Kryuchkova O. N., Lutai Yu. A., et al. Th e main provisions of the National clinical guidelines for the diagnosis, treatment, prevention of obesity and associated diseases. Crimean therapeutic journal. 2018; 4:5–11. (in Russ.)
Prilensky B. Yu., Vasilkova T. N., Bukhna A. G. Non psychotic mental disorders and clinical and laboratory characteristics of patients with non-alcoholic fatty liver disease. Siberian Bulletin of Psychiatry and Narcology. 2016; 4 (93): 86–92. (in Russ.)
Voronina L.P. Non-alcoholic steatohepatitis in the practice of a therapist // Medical news – 2009. – No. 4. – P. 26-29
Welsh JA, Karpen S, Vos MB. Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents 1998–1994 to 2007–2001. J Pediatr 2013; 162
