EVALUATION OF THE EFFICACY OF AN OINTMENT CONTAINING GOOSE FAT, EXTRACT ALOE, AND BETAMETHASONE IN PRECLINICAL STUDIES FOR THE TREATMENT OF ALLERGIC DERMATITIS
Keywords:
Goose fat, extract aloe, betamethasone, topical ointment, preclinical study, skin wound, regenerative activity, biological safety, toxicity, excision model.Abstract
This preclinical study, based on modern scientific principles, assessed the biological safety and regenerative efficacy of a topical ointment composed of goose fat, aloe, and Betamethasone. The experiments were conducted using a full-thickness excision wound model in albino rats. The ointment demonstrated no signs of acute toxicity, with treated animals showing stable clinical behavior and body weight. Application of the formulation led to significant acceleration of wound healing, with complete closure observed by day 14. Comparative analysis indicated superior efficacy of the experimental ointment compared to standard treatments. These findings confirm the high regenerative potential and safety profile of the goose fat-based formulation and support its relevance for further clinical development.
References
American Journal of Clinical Dermatology. (2018). Economic and psychosocial impact of chronic skin diseases: A review. Am J Clin Dermatol, 19(3), 339–351.
British Journal of Dermatology. (2021). Long-term safety of topical corticosteroids in atopic dermatitis. Br J Dermatol, 185(4), 695–705.
Clinical guidelines for contact dermatitis: Diagnosis and treatment depending on the affected area edited by R. Lewallen, A. Clark, S.R. Feldman. - M.: MEDpress-inform, 2016. - 96 p.
Elias PM, Wakefield JS. (2014). Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in atopic dermatitis. J Allergy Clin Immunol, 134(4), 781–791.
GBD 2019 Diseases and Injuries Collaborators. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019. The Lancet, 396(10258), 1204–1222.
Karimova F.R. All about allergic dermatoses. // Bukhoro Davlat Tibbiyot Institute. Bukhara, 2022. – P. 49-57.
Karimova F.R. Optimization of traditional medicine methods in the treatment of chronic allergic dermatitis // Journal of experimental research. Tashkent, 2024. – No. 3. – P. 39-46.
Mavlyanova Sh.Z., Muminova S.R., Boboev K.T. A method for diagnosing the severity of the clinical course of atopic dermatitis Dermatovenereology and aesthetic medicine. Scientific and practical journal 2016 74-77 p.
