FREQUENCY OF IL 12B GENE POLYMORPHISM AMONG PATIENTS WITH CHRONIC RHINOSINUSITIS POLYPOSIS
No. 3 (2022), Articles
No. 3 (2022)

FREQUENCY OF IL 12B GENE POLYMORPHISM AMONG PATIENTS WITH CHRONIC RHINOSINUSITIS POLYPOSIS

Articles
Published 2023-06-02
Ulugbek S. Khasanov
Ulugbek N. Vokhidov
Jamolbek A. Djuraev
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Keywords

paranasal sinuses, polyp, allele, genotyping

How to Cite

Ulugbek S. Khasanov, Ulugbek N. Vokhidov, & Jamolbek A. Djuraev. (2023). FREQUENCY OF IL 12B GENE POLYMORPHISM AMONG PATIENTS WITH CHRONIC RHINOSINUSITIS POLYPOSIS. Central Asian Journal of Medicine, (3), 5-15. Retrieved from https://journals.tma.uz/index.php/cajm/article/view/497
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Abstract

Analyzing the prevalence of genotypic variants of this polymorphism, we revealed a direct association of the C/C monogenotype of the A1188C rs3212227 polymorphism in the IL12B gene with the development of polyposis processes. In addition, these data emphasize the prognostic significance of the C/C genotype of the rs1800896 polymorphism of the IL-12B gene in the development of CPMS. In carriers of this genotype, the relative risk of developing CPMS increases by more than 3 times, compared with carriers of other genotypic variants of the rs3212227 polymorphism of the IL12B gene.

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