NEURODEGENERATION AS A COMPLICATION OF NONALCOHOLIC FATTY LIVER DISEASE (Review article)
Keywords:
nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, dementia, cognitive disorders, insulin resistance, neuroinflammation, neurodegeneration, liver-brain axis.Abstract
Non-alcoholic fatty liver disease (NAFLD) is now characterized as the hepatic manifestation of metabolic syndrome, is the leading cause of liver cirrhosis and currently affects a quarter of the world's population. A number of recent studies have focused on the prevalence of neurodegeneration, including dementia and cognitive impairment in NAFLD. Various risk factors, including insulin resistance, cerebrovascular dysfunction, intestinal dysbiosis, hyperammonemia, neuroinflammation and etc. Given the prevalence of NAFLD, its negative impact on cognitive function is a medical problem with enormous social and economic consequences. This article reviews the available evidence for the role of NAFLD in the development of neurodegeneration and describes possible mechanisms involved in the development of brain dysfunction in NAFLD.
