COMPARATIVE ANALYSIS OF FOLATE CYCLE MARKERS IN PATIENTS WITH TYPE 2 DIABETES COMPLICATED BY DIABETIC NEPHROPATHY

Authors

  • Barno Kh. Shagazatova
  • Said K. Bakhadirov
  • Bakhtiyor R. Mamasodikov

Keywords:

mitral valve genetic polymorphisms, diabetic nephropathy, markers

Abstract

One of the most studied genetic factors in the context of DN is the methylenetetrahydrofolate reductase (MTHFR) gene, specifically the C677T polymorphism. This single nucleotide polymorphism (SNP) is associated with elevated plasma homocysteine levels, which are known to contribute to vascular damage and the progression of nephropathy in diabetic patients. Research consistently shows that the 677T allele, particularly in individuals with the homozygous form (TT genotype), significantly increases the risk of developing DN across various populations.

Author Biographies

Barno Kh. Shagazatova

MD, DSc, Professor, Tashkent Medical Academy, Tashkent, Uzbekistan

Said K. Bakhadirov

Independent Researcher, Tashkent Medical Academy, Tashkent, Uzbekistan

Bakhtiyor R. Mamasodikov

Student, Central Asian University, Tashkent, Uzbekistan

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Published

2024-07-04

How to Cite

Barno Kh. Shagazatova, Said K. Bakhadirov, & Bakhtiyor R. Mamasodikov. (2024). COMPARATIVE ANALYSIS OF FOLATE CYCLE MARKERS IN PATIENTS WITH TYPE 2 DIABETES COMPLICATED BY DIABETIC NEPHROPATHY. Central Asian Journal of Medicine, (2), 97-104. Retrieved from https://journals.tma.uz/index.php/cajm/article/view/836

Issue

No. 2 (2024): CAJM

Section

Articles