RESULTS OF THE FREQUENCY OF OCCURRENCE OF ALLELES AND GENOTYPES OF THE RS3124954 986CT FCN2 GENE POLYMORPHISM IN VARIOUS FORMS OF CHRONIC TONSILLITIS

Abstract

The problem of treating chronic tonsillitis (CT) remains relevant in modern medicine, which is determined by the widespread prevalence of this disease, as well as the likelihood of developing serious complications and chronic diseases of the cardiovascular system, kidneys and joints. The incidence of CT in children has reached 25% of the total incidence in the structure of ENT diseases. One of the key links in the pathogenesis of infectious and infectious-allergic diseases, which include chronic tonsillitis, is the interaction of microorganisms with leukocytes (phagocytosis). In this case, bacteria secrete factors that inhibit the activation of complement, the activity of lysozyme, interferon, which affects their ability to survive in the conditions of the macroorganism and resistance to phagocytosis.