Central Asian Journal of Medicine

CORRELATION OF PROSTATE CANCER WITH DISEASES OF THE CARDIOVASCULAR SYSTEM AND TYPE 2 DIABETES

2024-02-18T18:10:58+00:00

This study examines the potential correlation between prostate cancer and two prevalent conditions: cardiovascular disease and type 2 diabetes. Prostate cancer is a significant global health issue, and comprehending its association with other common diseases is crucial for comprehensive patient care and public health initiatives. The study investigates the correlation between prostate cancer and cardiovascular diseases, including hypertension and atherosclerosis, as well as the correlation between prostate cancer and type 2 diabetes mellitus. The results provide insight into potential shared risk factors, underlying mechanisms, and implications for diagnosis, treatment, and prevention strategies for these diseases. This abstract summarises key aspects of the study, highlighting its importance in furthering the understanding of the complex relationships between prostate cancer and cardiovascular disease as well as type 2 diabetes.

LOCAL CYTOKINE THERAPY FOR DIABETIC FOOT SYNDROME

2024-02-18T18:21:44+00:00

Background. In recent years, the use of cytokines and various growth factors in the treatment of chronic wounds in patients with diabetes mellitus has been of great interest. This manuscript is devoted to this particular problem, which made it possible to improve the results of treatment. Material and methods. The results of the treatment of 72 patients with type 2 diabetes mellitus with diabetic foot syndrome are presented, consisting of two groups: the main group (38 patients who, along with the standard treatment of diabetic foot syndrome, underwent local applications with a solution of the immunomodulator Superlymph according to the generally accepted scheme) and the comparison group (34 patients who used traditional treatment for this pathology). Clinical, laboratory and instrumental research methods available in clinical settings were used. Results and conclusions. A change in the local cytokine status in the form of a decrease in anti-inflammatory and an increase in pro-inflammatory cytokines is characteristic of patients with diabetic foot syndrome. The levels of cytokines of wound discharge exudate depend on the duration of diabetes mellitus, and the level of glycated haemoglobin and leukocytosis and do not depend on the form of diabetic foot syndrome. The use of Superlymph in the complex therapy of patients with diabetic foot syndrome contributes to the normalization of the immune status, which in turn ensures effective healing of ulcerative foot defects in diabetic foot syndrome.

TREATMENT RESULTS EVALUATION OF PATIENTS WITH LOWER LIMB ARTERIAL THROMBOSIS AFTER CORONAVIRUS INFECTION

2024-02-18T18:26:05+00:00

An analysis of the results of surgical interventions in patients with thrombosis of the arteries of the lower extremities who suffered coronavirus infection was carried out. 42 patients were divided into 2 groups: the primary group, where endovascular thromboaspiration and systemic thrombolysis were performed to, and the control group, thrombectomy was performed to. On patients who undergone thrombectomy, in 2 cases, rethrombosis was detected in the early postoperative period, as well as in 2 cases, there was no regression of ischemia and as a result was performed high amputation. In the primary group, revascularization lead to limited necrotic zone formation in 1 case. Applying of endovascular thrombaspiration and thrombolysis over the thrombectomy significantly reduces the incidence of complications, retrothrombosis and mortality.

THE VALUE OF RETROGRADE ENDOSCOPIC METHODS IN THE DIAGNOSIS AND TREATMENT OF OBSTRUCTIVE JAUNDICE CAUSED BY CHOLEDOCHOLITHIASIS

2024-02-18T18:35:30+00:00

ACUTE TRACHEAL INJURY

2024-02-18T18:44:16+00:00

The purpose of this article is to examine the importance of improved coordination of care by an interprofessional team to improve outcomes for patients with tracheal injuries. Tracheal trauma is a time-dependent, high-risk acute condition that can adversely affect the patient's ability to maintain a patent airway. Optimal initial stabilization requires a team approach that includes emergency medicine, ENT, and ancillary services including respiratory therapy. Curative treatment, which involves emergency surgery, has been shown to lead to positive outcomes, as opposed to watchful waiting, which is associated with worse outcomes. The review article provides data on the diagnosis, methods and results of treatment of patients with acute trauma to the trachea and main bronchi. It is noted that only timely diagnosis, adequate surgical and anesthetic care can ensure a favorable treatment outcome.

METHOD AND IMPLEMENTATION OF SURGICAL CORRECTION FOR SPINE DEFORMATIONS

2024-02-18T18:47:00+00:00

ASSESSMENT OF THE PHARMACOLOGICAL EFFICACY OF A NEW ANTI-DIABETIC DRUG

2024-02-18T18:55:58+00:00

Diabetes mellitus is today one of the global medical and social problems in the health care system. According to the International Diabetes Federation (IDF), there were more than 425 million type II diabetes patients worldwide in 2019. Purpose of the study. To study preclinical pharmacological and toxicological studies of a new drug obtained on the basis and evaluate its hypoglycemic effect. Materials and research methods. The study of the acute toxicity of the new antidiabetic drug was carried out on 20 sexually mature white male rats with an initial body weight of 160-183 grams, exposed to intragastric doses of 500, 550, 600 and 650 mg / kg. The animals were injected intragastrically at 3.0 ml / 100 g. body weight. Research results. Observation of experimental animals with acute toxicity of the herbal preparation for 14 days, there were no pronounced symptoms of intoxication in animals. In groups of 6 animals receiving 550 mg / kg, 1 died, 1 received 600 mg / kg-2, and 650 mg / kg-4. Experienced animals responded adequately to external stimuli. Visible mucous membranes are moist, pale pink in color, shiny and smooth in appearance, no foci of baldness were found.

ASSESING THE EFFECTIVENESS OF TREATMENT FOR MIGRAINE PATIENTS USING THE MIGREN PRO MOBILE APPLICATION

2024-02-18T19:01:20+00:00

The article illustrates evaluating the effectiveness of treatment in patients using a mobile application in the treatment and controlling yhe migraine. The aim of the study is to improve migtaine behavioral skills and knowledge in patients who use the mobile application, to control medication intake, and to achieve the effectiveness of treatment without other additional drugs by monitoring the elimination of migraine triggers on a daily basis. During the research, 88 (100%) patients were observed. The patients were divided into two groups, the patients of the first group were recommended daily monitoring of migraine in paper form, and the patients of the second group were recommended the "MIGREN PRO" mobile application. All patients were re-examined after 3 months. In patients who used the mobile application, the number and duration of headache decreased, cognitive functions were restored, the level of depression decreased, and the quality of life improved.

LOCALIZATION OF NON-HODGKIN LYMPHOMAS IN CHILDREN

2024-02-18T19:05:25+00:00

Non-Hodgkin's lymphomas are a heterogeneous group of diseases that develop due to malignant monoclonal proliferation of lymphoid cells in the lymphoreticular tissue in the lymph nodes, bone marrow, spleen, liver and gastrointestinal tract. The most common symptom is peripheral lymphadenopathy. However, there are cases without lymphadenopathy, with the presence of circulating atypical lymphocytes. At the time of detection, the disease is likely to be disseminated, and the diagnosis is usually based on a biopsy of the lymph node or bone marrow, or both.

ROLE OF CYTOKINES IN THE DEVELOPMENT OF LIVER CIRRHOSIS, WHICH DEVELOPED AS A RESULT OF CHRONIC VIRAL HEPATITIS D (REVIEW ARTICLE)

2024-02-18T19:31:17+00:00

Hepatitis D is an inflammation of the liver caused by the hepatitis D virus (HDV), which requires HBV for its replication. Hepatitis D infection cannot occur in the absence of hepatitis B virus. HDV-HBV co-infection is considered the most severe form of chronic viral hepatitis due to more rapid progression towards hepatocellular carcinoma and liver-related death.

THE DEVELOPMENT OF ACUTE INFLAMMATORY CHANGES IN THE LUNGS AND THEIR TRANSITION TO PULMONARY FIBROSIS (LITERATURE REVIEW)

2024-02-18T19:41:12+00:00

Currently, acute and chronic lung diseases are the third most common cause of death, taking this place after cardiovascular and oncopathologies [1]. Despite the fact that acute inflammatory lung diseases, such as bacterial and viral pneumonia, successfully respond to etiotropic, pathogenetic and symptomatic therapy, in some cases severe and extensive damage to lung tissue occurs [2,3].

Acute lung injury (OPL) is a specific form of lung lesion characterized by extensive damage to the alveoli, non-cardiogenic pulmonary edema, as well as pulmonary and systemic neutrophil-associated inflammation, which leads to pulmonary insufficiency and hypoxemia [4-7]. Annually, OPL is diagnosed in more than 3 million patients worldwide, and mortality from this pathology varies from 35% to 46% [8,9]. Over the past few years, the incidence and mortality from OPL has increased significantly as a result of the pandemic of a new coronavirus infection caused by the SARS-CoV-2 virus (COVID-2019) [10,11].

MORPHOLOGICAL CHARACTERISTICS AND EXPERT ASSESSMENT OF CRANIOCEREBRAL INJURY

2024-02-18T19:48:37+00:00

The article is dedicated to morphological changes occurring in craniocerebral injury. Specifically, they often manifest as epidural, subdural, and subarachnoid hemorrhages. The sources of bleeding, their types, the mechanism of formation, and the morphological characteristics in craniocerebral injury are determined.

PREVALENCE, TYPES, MECHANISMS AND NATURE OF ORBIT INJURIES

2024-02-18T20:02:29+00:00

The article reflects a comprehensive analysis of aspects of forensic-medical expertise of orbital trauma. The issues related to the peculiarities of forensic-medical assessment of isolated and combined orbital trauma at the present stage are presented. The difficulties of expertise in these conditions are considered, which are determined, on the one hand, by the interdisciplinary nature of this pathology, and on the other hand, by the imperfection of the legal framework. The necessity of reviewing and reforming the existing legislative basis of forensic-medical expertise is substantiated.

CLINICAL, PROGNOSTIC AND BIOCHEMICAL MARKERS OF EARLY MANIFESTATIONS OF PARKINSON'S DISEASE AND METHODS OF THEIR CORRECTION

2024-02-18T20:14:56+00:00

Parkinson’s disease (PD) is a common neurodegenerative disease typified by a movement disorder consisting of bradykinesia, rest tremor, rigidity, and postural instability. Treatment options for PD are limited, with most of the current approaches based on restoration of dopaminergic tone in the striatum. However, these do not alter disease course and do not treat the non-dopamine-dependent features of PD such as freezing of gait, cognitive impairment, and other non-motor features of the disorder, which often have the greatest impact on quality of life. As understanding of PD pathogenesis grows, novel therapeutic avenues are emerging. These include treatments that aim to control the symptoms of PD without the problematic side effects seen with currently available treatments and those that are aimed towards slowing pathology, reducing neuronal loss, and attenuating disease course. In this latter regard, there has been much interest in drug repurposing (the use of established drugs for a new indication), with many drugs being reported to affect PD-relevant intracellular processes. This approach offers an expedited route to the clinic, given that pharmacokinetic and safety data are potentially already available. In terms of better symptomatic therapies that are also regenerative, gene therapies and cell-based treatments are beginning to enter clinical trials, and developments in other neurosurgical strategies such as more nuanced deep brain stimulation approaches mean that the landscape of PD treatment is likely to evolve considerably over the coming years. In this review, we provide an overview of the novel therapeutic approaches that are close to, or are already in, clinical trials.

COMPARATIVE CHARACTERISTICS OF ANTHROPOMETRIC INDICATORS IN ADOLESCENTS WITH DOWN SYNDROME (LITERATURE REVIEW)

2024-02-18T20:22:34+00:00

When it is called the development and formation of a child's organism, its comprehensiveness: includes complex stages and periods of mental and physical maturation, the peculiarities of individual variability and its relationship with factors of the internal and external environment that determine the physical development of children and adolescents [1].

Physical development is a dynamic process of growth and maturation of a child at different age periods of childhood, which is considered one of the main indicators of the state of Health [3, 8].

THE STAGES OF POSTURE FORMATION AND VARIOUS FACTORS LEADING TO A CHANGE IN POSTURE (LITERATURE REVIEW)

2024-02-18T20:29:09+00:00

Posture has attracted the attention of doctors and scientists since time immemorial. Early studies were exclusively practical in nature and were associated with pathological conditions of the spine. Hippocrates (460-377 BC) wrote several works on spinal curvature, in which he proposed methods for correcting body posture defects in the form of breathing exercises [9]. An equally popular ancient physician Galen from Pergamon described the treatment of scoliosis with the help of breathing exercises, singing and special chest bandaging [3]. It was he who first introduced the concepts of lordosis, kyphosis and scoliosis.

A NEW APPROACH TO THE TREATMENT AND PREVENTION OF MORPHOFUNCTIONAL CHANGES IN THE HEART AS A RESULT OF THE EFFECTS OF VARIOUS FACTORS OF THE EXTERNAL AND INTERNAL ENVIRONMENT (LITERATURE REVIEW)

2024-02-18T20:32:33+00:00

Cardiovascular diseases are the most common causes of morbidity and mortality worldwide. Redox dysregulation and a dyshomeostasis of inflammation arise from, and result in, cellular aberrations and pathological conditions, which lead to cardiovascular diseases. Despite years of intensive research, there is still no safe and effective method for their prevention and treatment. Recently, molecular hydrogen has been investigated in preclinical and clinical studies on various diseases associated with oxidative and inflammatory stress such as radiation-induced heart disease, ischemia-reperfusion injury, myocardial and brain infarction, storage of the heart, heart transplantation, etc. Hydrogen is primarily administered via inhalation, drinking hydrogen-rich water, or injection of hydrogen-rich saline. It favorably modulates signal transduction and gene expression resulting in suppression of proinflammatory cytokines, excess ROS production, and in the activation of the Nrf2 antioxidant transcription factor. Although H₂ appears to be an important biological molecule with anti-oxidant, anti-inflammatory, and anti-apoptotic effects, the exact mechanisms of action remain elusive. There is no reported clinical toxicity; however, some data suggests that H₂ has a mild hormetic-like effect, which likely mediate some of its benefits. The mechanistic data, coupled with the pre-clinical and clinical studies, suggest that H₂ may be useful for ROS/inflammation-induced cardiotoxicity and other conditions.

THE NEGATIVE EFFECT OF LONG-TERM CHEMOTHERAPY ON HEART FUNCTION

2024-02-18T20:38:40+00:00

Recovery from chemotherapy can take place in different ways for different patients and depends on several factors, such as the type and dose of chemotherapy drugs used, the duration of treatment, as well as the general state of health and the level of physical fitness of a person. Typically, the immediate side effects of chemotherapy may persist for several days or weeks after treatment and may include fatigue, nausea and vomiting, hair loss, mouth ulcers, and changes in appetite or taste. These side effects can be managed with medications, dietary changes, and other supportive treatments, and they usually go away over time. There may also be long-term side effects of chemotherapy, such as nerve damage, hearing loss and an increased risk of infection, which may persist for months or years after treatment. For those who have received chemotherapy, it is important to monitor these potential long-term effects and receive appropriate follow-up treatment.

THE STUDY OF THE EFFECT OF RADIATION AND CHEMOTHERAPY ON THE FUNCTION OF THE HEART

2024-02-18T20:43:30+00:00

The effect of chemoradiotherapy (CLT) on the cardiovascular system has been known since the 70s [4]. The dose-dependent cardiotoxicity of anthracycline antibiotic metabolites has been most well studied [6], which usually manifests itself already during treatment or in the first months and years after its completion.

The most common of the early clinically significant cardiac complications of radiation therapy is effusion pericarditis. Lesions of the coronary arteries, valves, pericardial constriction and chronic heart failure (CHF), caused by progressive sclerotic changes in all structures of the heart, make their debut much later [3].

VIOLATION OF CALCIUM-PHOSPHORUS METABOLISM IN CHILDREN OF A PATIENT WITH CHRONIC PYELONEPHRITIS (LITERATURE REVIEW)

2024-02-18T20:50:00+00:00

The state of the organism is formed by various factors of the internal and external environment, among which the state of calcium-phosphorus metabolism occupies an important place.

Violation of the structure and function of the organs involved in the regulation of phosphorus-calcium metabolism is the cause of various diseases that develop during the life of the child.

The kidneys are the main organ in the regulation of phosphorus-calcium homeostasis in both physiological and pathological conditions.

ANALYSIS OF THE IMMUNITY INDICATORS OF PREMATURE NEWBORNS DEPENDING ON THE TYPE OF NUTRITION

2024-02-18T20:54:02+00:00

The article discusses some aspects of the functioning of the immune system of a premature baby, in particular the cytokine status. A separate part of the article is devoted to the intestinal microbiota and the role of breast milk in the formation and development of immune functions.

A SPECIALIST'S VIEW ON THE EPIDEMIOLOGICAL DESCRIPTION OF TORCH-GROUP INFECTIONS (REVIEW ARTICLE)

2024-02-18T20:59:08+00:00

The high comparative weight of TORCH-group infections affects both the demographic condition and the health of the mother and child. The most medically-socially significant specificity of TORCH-group infections is their destructive effect on all organs and systems of the fetus and, above all, its central nervous system, this effect increases the risk of miscarriage, stillbirth and the child's integrity, the formation of defects in its development and leading to disability. In this regard, among TORCH-group infections, toxoplasmosis, rubella, cytomegaly viral infection, as well as infections that call the simple herpes virus Type 1 and 2 are of particular epidemiological importance.

THE EFFECTIVENESS OF ULTRASOUND IN THE DIAGNOSIS OF CHOLECYSTITIS

2024-02-18T21:02:47+00:00

The use of ultrasound for cholecystitis makes it possible to make a correct diagnosis in the shortest possible time, determine subsequent treatment tactics, and promptly begin conservative or surgical treatment. Timely diagnosis of damage to the gallbladder and bile ducts, congestion of the extrahepatic and intrahepatic bile ducts. The creation of laboratory panels to assess the severity and severity of the pathological process during exacerbation of chronic or latent forms of this disease is important. Acute cholecystitis is one of the most significant acute diseases of the abdominal organs.

MORPHOLOGICAL AND HISTOMORPHOMETRIC CHARACTERISTICS OF THE THYROID GLAND OF WHITE OUTBREED RATS

2024-02-18T21:06:21+00:00

Thyroid pathology is the second most common endocrinopathy after diabetes mellitus. The number of patients with temporary and permanent disabilities due to thyroid pathology is growing. Early diagnosis of morphological changes in pathologies of the thyroid gland and increasing the effectiveness of treatment are undoubtedly carried out with knowledge of the normal parameters of the thyroid gland. This article examines the morphological and histomorphometric characteristics of the thyroid gland of purebred rats.

FEATURES OF HUMORAL IMMUNITY INDICATORS IN THE BLOOD SERUM OF PATIENTS WITH ADENOVIRAL CONJUNCTIVITIS BEFORE AND AFTER TREATMENT

2024-02-18T21:09:46+00:00

Inflammatory eye diseases of viral, bacterial and mixed etiology are widespread and are a serious medical and social problem, accounting for more than 40% of all outpatients. The most common agents that cause damage to the organ of vision are adenoviruses (ADVs). Adenoviral eye damage occurs in 10-12% of all cases of adenoviral damage to the body. In addition, adenoviruses remain the most common causative agents of hospital ophthalmic infections. In addition to acute forms, adenoviral eye infection can also occur in the form of chronic and recurrent forms, the proportion of which is currently difficult to estimate.

MORPHOMETRIC INDICATORS OF THE FACIAL SKELETON IN INDIVIDUALS WITH COMPLETE AND PARTIAL ADENTIA

2024-02-18T21:16:34+00:00

In scientific research, dentists focus on individual changes found in the jaw-face area. One of the main methods for assessing indicators in the tooth-jaw system is based on the fact that morphometric indicators determine the compatibility of tooth sizes with the indicators of the tooth-jaw. Therefore, it is advisable to study and identify topographic identities of anatomical derivatives of the jaw-facial area before orthopedic, orthodontic treatment of patients with dental-jaw research using biometric studies [1, 3].

GENERAL CHARACTERISTICS OF PATIENTS WITH BRONCHIAL ASTHMA AND COMPLEX PROCEDURES OF DENTAL EXAMINATION

2024-02-18T21:29:36+00:00

Bronchial asthma is a serious problem in all countries of the world, including the Republic of Uzbekistan, which is also associated with a clear increase in the frequency of occurrence, the number of complications, exacerbation of the disease [1,6,7].

Studies in recent years have shown that about 2 million people in Uzbekistan suffer from bronchial asthma, of which about 1 million have severe forms of the disease. The prevalence rates for patients with bronchial asthma among the population are 30% mild , 50% moderate, and 20% severe bronchial asthma patients [5].

Bronchial asthma causes disability and major economic damage in the population. High rates of bronchial asthma have been reported in Uzbekistan. In 2019-2022, its prevalence in the Fergana region was studied, accounting for 7.2% [1].

Bronchial asthma has a single immune-inflammatory form that also affects the organs of the oral mucosa and the respiratory tract. In patients with bronchial asthma, the oral cavity has a significant effect on the decrease in the protective properties of the mucous membrane, which creates unfavorable conditions for the hard tissues of the tooth and periodont tissue, increases the effect of microflora and other pathogenic factors. There is information about the presence of disorders in the immune system in patients with bronchial asthma who are prone to the occurrence of inflammatory periodontal diseases [2,4,9].

Both an attack of bronchial obstruction and a relatively calm period of the disease require the appointment of medications, in particular glucocorticosteroids. At the same time, along with a positive effect, these drugs lead to a decrease in the natural protective barrier of the oral mucosa and dysfunction of immune defense systems. This can significantly complicate adequate therapy of the disease, contributing to the development or progression of local and general inflammatory diseases [11,12].

With the beginning of the use of glucocorticosteroids, the results of preventive and maintenance therapy of bronchial asthma have improved significantly, but currently the effect of these drugs on the condition of the oral mucosa is little studied. Studies have not been carried out in patients with bronchial asthma, taking into account the condition of the oral cavity, the clinical and pathogenetic variant, duration and methods of this disease [4].

MORPHOLOGICAL FEATURES OF MESENTERIAL LYMPH NODES IN EXPERIMENTAL HYPOTHYROIDIS IN THE MOTHER

2024-02-18T21:36:00+00:00

According to statistics, half of the world's population has health problems related to the thyroid gland.

The effect of experimental hypothyroidism in female rats on the development, formation and growth of mesenteric lymph nodes (MLN) of the offspring was studied.

Hypothyroidism in female rats was induced by oral administration of the antithyroid drug Mercazolil at a dose of 0.5 mg per 100 g of body weight for 21 days. After establishing a stable decrease in the concentration of free thyroxine in the blood serum, the females were fertilized by healthy males. During pregnancy and lactation, females continued to be administered a maintenance dose of the drug.

At 3, 7, 14, 21 and 30 days after birth, the development and formation of MLN offspring obtained from females with experimental hypothyroidism were morphologically studied.

It has been established that in offspring born under conditions of maternal hypothyroidism, the time parameters for the formation of structural and functional zones of MLN, especially its T-dependent zones, significantly lag behind the control.

CLINICAL AND LABORATORY MANIFESTATIONS OF TUBERCULOUS SPONDYLITIS

2024-02-18T21:40:19+00:00

The purpose of our study was to characterize the clinical and laboratory features of tuberculous spondylitis at the level of the general medical network.

Materials and methods. Comprehensive examination of 110 patients with tuberculous spondylitis was conducted in the department of tuberculosis of bones and joints of the Republican Specialized Scientific and Practical Medical Center of Phthisiology and Pulmonology.

Results. The study results showed decrease of blood hemoglobin levels and erythrocytes count in patients with tuberculous spondylitis. Blood acute-phase proteins were increased several times in patients with tuberculous spondylitis. Blood coagulation biochemical markers analyses showed an increased level of fibrinogen and D-dimers.

Conclusion. Clinical and laboratory manifestations of tuberculous spondylitis in modern conditions are characterized by mild anemia, an increase in the blood of acute-phase proteins, fibrinogen, D dimers, reactive hepatitis and decrease of the blood fibrinolytic activity.

AN INTEGRATED APPROACH TO THE SELECTION OF EMBRYOS USING AUXILIARY REPRODUCTIVE TECHNOLOGIES IN INCREASING THE EFFECTIVENESS OF FETAL RESULTS

2024-02-18T22:37:50+00:00

Cryopreservation of gametes and embryos is one of the most pressing problems of modern reproductive medicine. A comparative analysis of the effectiveness of the use of natural and frozen materials was carried out in the embryological laboratory. With the help of carriers of the closed (n = 598) and open (n = 665) types, 1263 molten embryos were transferred. Most of the indicators were good when using open carriers. The data obtained allows us to conclude that vitrification of morphologically normal gametes does not reduce the effectiveness of cryodastures and maintains their reproductive status. The use of open-type carriers to vitrify and store embryos demonstrates high levels of embryo retention after cryoconservation, with rates of miscarriage and low loss. It is assumed that this is due to the direct contact of the biological object (embryo) with liquid nitrogen and high freezing levels, which can be a decisive factor in the successful determination of vitrification in open carriers.

DEVELOPMENT OF AN ALGORITHM FOR DETECTING DENTAL DISEASES AND PROVIDING DENTAL CARE TO CHEMICAL INDUSTRY WORKERS

2024-02-18T22:41:01+00:00

The question of the negative impact of some industries on the oral cavity remains relevant. The relationship of the high prevalence of non-carious lesions of the teeth and oral mucosa with such industrial processes as oil and gas extraction, metallurgy, chemical production, bakery and confectionery production has been proven. Dental health contributes to the preservation of the ability to work of an important part of the non–population of the country - workers of industrial enterprises, especially since a number of studies convincingly reveal the role of the dental system in the general state of the body. [2,6,8,]

The presence of high risks of occupational diseases among workers in industry has been proven. This is due to the entry of compounds of elements into the human body through the oral cavity. Industrial workers are characterized by a high prevalence of dental caries and inflammatory periodontal diseases.

THE COURSE OF DIABETIC POLYNEUROPATHY IN THE COMORBID DEFICITIES OF THE BODY (CLINICAL CASE)

2024-02-18T22:44:55+00:00

Today, the incidence of diabetes mellitus (DM) in the population is increasing at very high rates worldwide. Diabetic polyneuropathy (DPN) is the most common complication of diabetes mellitus (DM) in the peripheral nervous system. A common clinical form of DPN is a distal symmetrical, mainly sensory, polyneuropathy. The basis of the pathogenesis of DPN is chronic hyperglycemia, which leads to the accumulation of excess intermediate products in various organs and tissues, including damage to the vasa nervorum, which is involved in the blood supply of peripheral nerves. This article examines the deficiency states of the body in the case of diabetic and comorbid polyneuropathy.

CHANGES IN THE HISTOARCHITECTONICS OF THE KIDNEYS IN POSTNATAL ONTOGENESIS DURING ALCOHOL INTOXICATION

2024-02-18T22:48:33+00:00

The results of the study showed that 30% of rats who consumed alcohol for 30 days developed an apoptosis ulcer in the kidneys. In 9-year-old squids who consumed alcoholic beverages for 120 days, morphological changes were observed in the kidneys, that is, in the podocytes located in the kidneys, which indicates a decrease in the expression of the Ki-67 marker during apoptosis. The proliferative activity of pathocytes is manifested in intercellular interactions.

COMPREHENSIVE ASSESSMENT AND IMPROVEMENT OF THE QUALITY OF LIFE OF CHILDREN WITH CONGENITAL CLEFT LIP AND PALATE

2024-02-18T22:51:55+00:00

The study and improvement of the life status of children with congenital cleft lip and palate using temporary silicone nipples and plates showed a positive effect on the development of speech defects and on the anthropometric parameters of the maxillae and dentoalveolar arch.

135 infants born with CCLP were recruited, of which 83 were male and 52 were female. The babies were divided into 2 groups. Group 1 - the main group of 68 infants (of which 42 are male and 26 are female) and group 2 - the control group of 66 infants (of which 41 are male and 26 are female).

The studied changes and their systematization lead to a decrease in maxillofacial pathologies, as well as growth and development of the definition, which contributes to the non-hormonal development of the child. The introduction of the obtained data into practical healthcare will reduce the proportion of maxillofacial anomalies. For the first time, the method of using early orthodontic treatment of children with CCLP, carried out with the help of the "Dental Obturator for orthodontic treatment of children with CCLP" was scientifically substantiated.