EPIGENETIC AND IMMUNOLOGICAL CHANGES IN THE OCCURRENCE OF ATOPIC DERMATITIS

Abstract

Changes in the genetic background and the impact of a deteriorating ecosystem lead to the development of a large number of allergic diseases, which also became a prerequisite for the study of the etiological theory of the origin of atopic dermatitis. In this aspect, epigenetic changes are in the first place. Genetic changes cannot explain such a rapid increase in the incidence of atopic dermatitis. Changing environmental factors such as Western lifestyles, industrialization, air pollution, changing diets, obesity, increased use of antibiotics, and smoking are coming to the fore. Epigenetic changes are a probable mechanism of environmental influence on the cells of the body. When describing the etiological factors of the development of atopic dermatitis, it is impossible not to note the role and place of immunological regulation and reaction. This review article is devoted to the study of literature information regarding epigenetic and immunological aspects in the development of atopic dermatitis.