JOURNAL OF EDUCATION AND SCIENTIFIC MEDICINE

CORRELATIONS OF CAROTID ARTERY STENOSIS AND CONTRALATERAL COMPENSATORY MECHANISMS IN ISCHEMIC STROKE SUBTYPES

2025-03-09T00:59:18+00:00

Background: Carotid artery stenosis significantly affects the risk of IS by affecting cerebral blood flow. Narrowing of the carotid arteries may lead to decreased perfusion of the brain, which may provoke neurological deficits. Moreover, the body may activate compensatory mechanisms to maintain adequate cerebral blood flow despite significant narrowing of the arteries. Understanding the relationship between carotid artery stenosis and cerebral blood flow velocity is important for effective clinical decision making and patient management.

Results: There were no significant differences between the 2 groups in terms of clinical characteristics of the patients included in the study. The average clinical score in patients with two subtypes of IS first day of hospitalization was 17.8±3.2 on the NIHSS scale and 4,5±0,5 on the modified Rankin scale, which corresponds to moderate to severe level of the disease.

Conclusion: This study highlights the complex relationship between carotid artery stenosis and cerebral hemodynamics, which has important implications for the management and treatment of these patients.

INTERNATIONAL SURGICAL WOUND COMPLICATIONS ADVISORY PANEL GUIDELINE FOR POST-OPERATIVE INCISION CARE

2025-03-17T11:10:31+00:00

EPIGENETIC AND IMMUNOLOGICAL CHANGES IN THE OCCURRENCE OF ATOPIC DERMATITIS

2025-04-01T04:40:51+00:00

Changes in the genetic background and the impact of a deteriorating ecosystem lead to the development of a large number of allergic diseases, which also became a prerequisite for the study of the etiological theory of the origin of atopic dermatitis. In this aspect, epigenetic changes are in the first place. Genetic changes cannot explain such a rapid increase in the incidence of atopic dermatitis. Changing environmental factors such as Western lifestyles, industrialization, air pollution, changing diets, obesity, increased use of antibiotics, and smoking are coming to the fore. Epigenetic changes are a probable mechanism of environmental influence on the cells of the body. When describing the etiological factors of the development of atopic dermatitis, it is impossible not to note the role and place of immunological regulation and reaction. This review article is devoted to the study of literature information regarding epigenetic and immunological aspects in the development of atopic dermatitis.

HYGIENIC ANALYSIS AND WAYS TO IMPROVE THE EDUCATIONAL PROCESS OF MIDDLE SCHOOL STUDENTS

2025-04-20T15:48:14+00:00

The study analyzed the organization of the educational process for 5th to 7th-grade students at School No. 51 in the Toshloq District of Fergana Region, assessing compliance with the requirements of SanPiN No. 0341–16 "Sanitary and Epidemiological Requirements for Conditions and Organization of Education in Public Schools." The educational activity in the school was evaluated based on chronometry. The monitored school has eight middle school classes, which attend classes in a six-day schedule during the first shift. In 5-A class, there are 34 students (9 over the norm), in 5-B class there are 30 students (5 over the norm), in 6-A class there are 31 students, 6-B class has 28 students (3-6 over the norm), and it was determined that in grades 7-8 there are 1-3 students less than expected. The daily workload for grades 5-8 was 5-6 hours, and the total time spent in school was 8.4 and 9.0 hours, constituting 73.3-81.6% of time in middle grades. The weekly workload for middle school students is 29 hours in 5th grade, which is 3 hours less than the norm; in 6th grades, it is 30 and 31 hours (norm is 33 hours); the 7th grade meets the norm, and in the 8th grade, it is 2-3 hours below the norm. The structure of the class schedule for middle school students does not meet hygienic requirements, with complex lessons scheduled for the first and last periods on all days of the week. For example, in 7-B class on Monday, the Uzbek language and chemistry were scheduled in periods 1-2, while physics and a foreign language are in periods 4-5. On Saturday, the subjects include Uzbek language, algebra, foreign language, and geometry during periods 2-3-4-5. In challenging weeks, the complexity level of lessons in the 5th grade ranged from 24 to 28 points, while on Saturday it was 38-36 points. In the 6-A class, the complexity was 42 points on Monday, 29-22 points on Wednesday, 47-49 points on Friday, and 34 and 46 points on Saturday. In the 7-A class, it was 55 points on Monday, 50 points on Friday, and 38-55 points on Saturday. In the 8th grade, complexity was 35-43 points on Monday, 33-24 points on Tuesday, and 39-52 points on Saturday. The complexity of lessons was not considered. If measures are not developed to improve this situation, it will not only decrease students' ability to work but also create conditions for their nervous-psychological state to deteriorate and the development of somatic diseases.