JOURNAL OF EDUCATION AND SCIENTIFIC MEDICINE

CORRELATIONS OF CAROTID ARTERY STENOSIS AND CONTRALATERAL COMPENSATORY MECHANISMS IN ISCHEMIC STROKE SUBTYPES

Z.R. Egamnazarova — 2025-04-01

Background: Carotid artery stenosis significantly affects the risk of IS by affecting cerebral blood flow. Narrowing of the carotid arteries may lead to decreased perfusion of the brain, which may provoke neurological deficits. Moreover, the body may activate compensatory mechanisms to maintain adequate cerebral blood flow despite significant narrowing of the arteries. Understanding the relationship between carotid artery stenosis and cerebral blood flow velocity is important for effective clinical decision making and patient management.

Results: There were no significant differences between the 2 groups in terms of clinical characteristics of the patients included in the study. The average clinical score in patients with two subtypes of IS first day of hospitalization was 17.8±3.2 on the NIHSS scale and 4,5±0,5 on the modified Rankin scale, which corresponds to moderate to severe level of the disease.

Conclusion: This study highlights the complex relationship between carotid artery stenosis and cerebral hemodynamics, which has important implications for the management and treatment of these patients.

INTERNATIONAL SURGICAL WOUND COMPLICATIONS ADVISORY PANEL GUIDELINE FOR POST-OPERATIVE INCISION CARE

A.O. Okhunov, S. Carvalhal, M.Rochon, et al. — 2025-04-01

EPIGENETIC AND IMMUNOLOGICAL CHANGES IN THE OCCURRENCE OF ATOPIC DERMATITIS

G.R. Razikova — 2025-03-31

Changes in the genetic background and the impact of a deteriorating ecosystem lead to the development of a large number of allergic diseases, which also became a prerequisite for the study of the etiological theory of the origin of atopic dermatitis. In this aspect, epigenetic changes are in the first place. Genetic changes cannot explain such a rapid increase in the incidence of atopic dermatitis. Changing environmental factors such as Western lifestyles, industrialization, air pollution, changing diets, obesity, increased use of antibiotics, and smoking are coming to the fore. Epigenetic changes are a probable mechanism of environmental influence on the cells of the body. When describing the etiological factors of the development of atopic dermatitis, it is impossible not to note the role and place of immunological regulation and reaction. This review article is devoted to the study of literature information regarding epigenetic and immunological aspects in the development of atopic dermatitis.