STUDY OF THE VARIABILITY OF Y CHROMOSOMAL MICROSATELLITE LOCI CHARACTERISTIC TO UZBEK POPULATION

Abstract

Aimed to investigate the haplotypes and allele frequencies for the 17 Y-STR loci in Uzbekistan population.
Material and Methods: The subjects of the study were blood samples and dried saliva on sterile gauze tampons, selected
from 1900 individuals. Results: This population was demonstrated 1000 haplotypes, of which 899 (Tashkent – 100,
Fergana – 73, Andijan – 84, Namangan – 36, Sirdarya – 54, Djizax – 77, Samarqand – 77, Kashqadarya – 71, Surxandarya
– 46, Buxara – 97, Navoiy – 48, Xorezm – 90 and from Republic Karakalpakistan – 93) were unique. The gene diversity was
0.996 (standard error: 0.005). The haplotype diversity calculated from the 17 Y-STR loci was 0.899 and the discrimination
capacity was 0.9223. The DYS385 locus showed the highest gene diversity value (0.8936), while the DYS437, DYS389I,
DYS391, DYS392 loci showed the lowest gene diversity value (0.49-0,55). This database of 17 Y-STR loci for the Uzbekistan
population would be useful in forensic examinations and human genetic studies. Conclusions: Studies of the variability
of 17 Y-STR loci in the Y-chromosome of the Uzbek population have demonstrated a high level of heterogeneous diversity
of the gene pool of the indigenous population of Uzbekistan. Getting the result showed a mixed nature of the population