MANIFESTATIONS OF VASCULAR COMPLICATIONS IN EXPERIMENTAL DIABETES MELLITUS

Abstract

Objective: The morphological and functional disorders of the pancreas and blood vessels of the lower limb of rats
with experimental diabetes mellitus. Material and methods: The object of the study were 90 white rats at the age of
4-6 months. The morphological changes of the pancreas and the walls of blood vessels of the lower limb in experimental
diabetes mellitus. Model of experimental diabetes reproduced by single intraperitoneal administration of streptozotocin
Wistar rats at a dose of 60 mg/kg. Results: Comparison of the mass of bodies of rat control and experimental
group showed that during the experiment, the experimental group of rats had plenty in development compared to the
control group by 1.7 times. In all the experiments in terms of pancreatic islets was observed moderate lymphocytic
infiltration. Morphological examination of the vessels in different time postnatal ontogenesis demonstrated that compared
with the control group in the form of changes in the delay of progression and formation of individual components
vascular wall. Destructive changes in the arterial wall marked us all experimental animals from the early days
after the experiment. Conclusion: The results indicate that the type 1 diabetes the pancreas causes changes and limbs.