COMPARATIVE EVALUATION OF HEPATOPROTECTIVE EFFECTS OF KATACIN AND GERANIL ON A MODEL OF ACUTE TOXIC LIVER DAMAGE

Abstract

to evaluate the effectiveness of new domestic drugs (cavergal, geranyl and catacin) in the correction of the
main hepatic syndromes: cytolysis, cholestasis, mesenchymal inflammation and hepatocellular insufficiency in a model of
toxic liver damage. Material and methods: studies were conducted on 75 male rats with acute toxic liver damage, which was
reproduced by administering heliotrin at a dose of 200 mg / kg, 8 rats were included into intact group. Biochemical studies
of blood serum were performed on a biochemical analyzer. Results: experimental pharmacotherapy of acute toxic liver
damage with new drugs katatsin and geranil significantly reduced rates of cytolysis, cholestasis, mesenchymal inflammation.
The preparations increased the protein synthesis function of the liver. According to hepatoprotective properties, catacin and
geranil were not inferior to Karsil to the hepatoprotector and significantly outperformed the antihypoxant of the cavergal.
Conclusion: the plant flavonoids catacin and geranyl have pronounced hepatoprotective properties.