OUR EXPERIENCE IN THE TREATMENT OF VITILIGO WITH TRANSPLANTATION OF EPIDERMOCYTES OF OUR OWN SKIN

Abstract

Objective: A clinical assessment of the effectiveness of the technology for producing epidermocytes of the skin and
their transplantation onto depigmented skin areas. Material and methods: Under observation were 28 patients (19
women, 9 men) with various forms of vitiligo aged 19-35 years with 48 foci of vitiligo with disease duration from 4
to 15 years; Duration of patient monitoring – 12 months. The distribution of patients according to skin phototypes
according to Fitzpatrick showed that with III skin phototype there were 22 patients; with phototype II – 6. Results:
Treatment with transplanted uncultured epidermal cells in 28 patients with vitiligo included several stages. Dermabrasion
of the lesion was performed by a dermabrider. Epidermal grafts for transplantation were obtained by cutting
off the covers of the blisters obtained at a negative pressure of 200-300 mm RT. Art. After 10-12 PUVA sessions, 19
patients showed complete repigmentation of 19 foci; repigmentation in 75-80% of the area – in 15 foci; on 50% of the
area – in 10 outbreaks, less than 50% - in 4 outbreaks. The greatest effect was obtained in patients with localization
of foci of depigmentation on the trunk and proximal limbs and with III skin phototype. The achieved result was maintained
throughout the observation period (12 months). Conclusions: The use of the method of transplantation of epidermocytes
of their own skin in the treatment of various forms of vitiligo is an affordable and very promising method
of therapy, which allows to achieve a pronounced lasting effect without complications.