COMPARATIVE DATA OF VARIOUS INDICATORS OF HPV PHYLOGENETIC GROUPS

Abstract

Objective: To study the prevalence of phylogenetic groups of HPV, as well as the degree of its clinical significance among
women of childbearing age in the Republic of Uzbekistan. Material and methods: For the period from 2015 to 2018. In the Republican
Specialized Scientific-Practical Medical Center for Obstetrics and Gynecology, 6431 women aged 18 to 65 years were
examined to determine the phylogenetic group of HPV. Testing was carried out in real-time mode, which allows differentiating
12 HPV genotypes of high carcinogenic risk. Results: The prevalence of HPV in the phylogenetic groups A5/A6, A7, A9 among
age groups repeats the epidemiology of HPV on a global scale. The level of HPV detection begins at 20 years old, increases with
age, reaching its maximum at the age of 25 to 35 years, and then there is a decrease in its – detection. The most common type
is A5 / A6 (51 and 56 types) – in 631 (54.2±1.4) cases, A7 – in 508 (18, 39, 45, 59 types) (43.6±1.4) cases, A9 (16, 31, 33, 35, 52,
58) – in 331 (28.4±1.3) cases, while the indicators were statistically significantly different from each other (p<0.001). The higher
the concentration of viruses, the lower the age of the patients, which varies between 25-30 years in all phylogenetic groups and
has an inverse correlation dependence. Conclusions: Prevention of the spread of the human papillomavirus by introducing
vaccination is necessary, as well as screening studies of women for the prevention of cervical cancer