Abstract
Abnormal uterine bleeding (AUB) associated with endometrial dysfunction remains one of the most prevalent and clinically significant conditions in gynecological practice. This study proposes and clinically validates an optimized algorithm for the diagnosis and treatment of AUB in women of reproductive age. A total of 100 women with confirmed endometrial dysfunction were enrolled and stratified into two age groups. A comprehensive diagnostic approach based on clinical, hormonal, morphological, and immunohistochemical evaluation significantly increased diagnostic accuracy and achieved clinical improvement in 80–88% of cases. Implementation of the algorithm was associated with reduced recurrence rates, improved quality of life, and decreased need for surgical intervention. The findings support the high clinical applicability and reproducibility of the proposed strategy.