THE ROLE OF MOLECULAR GENETIC MARKERS IN THE CLINICAL COURSE OF CERVICAL INTRAEPITHELIAL NEOPLASIA

Authors

  • Dilbar Nazhmutdinova Tashkent Medical Academy
  • Iroda Kamilova Tashkent Medical Academy
  • Umida Shukurova Tashkent Medical Academy

Keywords:

Cervical intraepithelial neoplasia, Genes of oncosuppressor proteins – TP53, Genes of enzymes of estrogen metabolism – CYP1A2, SULT1A1, Genes of matrix metalloproteinases – MMP-1, Urogenital infection

Abstract

When studying the clinical course of cervical intraepithelial neoplasia in 226 women with molecular genetic analysis, it was revealed that the correlation of alleles and genotypes of genes of oncosuppressor proteins, enzymes of estrogen metabolism and matrix metalloproteinases, confirmed by indicators of relative risk, were the basis for establishing the severity of the clinical course and the risk of developing this multifactorial pathology, by studying anamnestic, somatic data, complaints and the presence of urogenital infections in women with neoplasia of the cervical epithelium.

 

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Published

2022-05-25

How to Cite

Nazhmutdinova , D., Kamilova , I., & Shukurova , U. . (2022). THE ROLE OF MOLECULAR GENETIC MARKERS IN THE CLINICAL COURSE OF CERVICAL INTRAEPITHELIAL NEOPLASIA. JOURNAL OF EDUCATION AND SCIENTIFIC MEDICINE, (2), 17-19. Retrieved from https://journals.tma.uz/index.php/jesm/article/view/262

Issue

No. 2 (2022): JESM 2022 N2

Section

Articles