FREQUENCY OF IL 12B GENE POLYMORPHISM AMONG PATIENTS WITH CHRONIC RHINOSINUSITIS POLYPOSIS

Authors

  • U.S. Khasanov Department of Otorinolarynology and Stomatology, Tashkent Medical Academy, Republic of Uzbekistan
  • U.N. Vokhidov Department Otorinolaryngology, Tashkent State Dental Institute, Republic of Uzbekistan
  • J.A. Djuraev Department of Otorinolarynology and Stomatology, Tashkent Medical Academy, Republic of Uzbekistan

Keywords:

paranasal sinuses, polyp, allele, genotyping

Abstract

Analyzing the prevalence of genotypic variants of this polymorphism, we revealed a direct association of the C/C monogenotype of the A1188C rs3212227 polymorphism in the IL12B gene with the development of polyposis processes. In addition, these data emphasize the prognostic significance of the C/C genotype of the rs1800896 polymorphism of the IL-12B gene in the development of CPMS. In carriers of this genotype, the relative risk of developing CPMS increases by more than 3 times, compared with carriers of other genotypic variants of the rs3212227 polymorphism of the IL12B gene..

Author Biographies

U.S. Khasanov, Department of Otorinolarynology and Stomatology, Tashkent Medical Academy, Republic of Uzbekistan

Khasanov Ulugbek Saidakramovich – DSc, professor, Head of the Department of Otorinolarynology and Stomatology, Tashkent Medical Academy, Republic of Uzbekistan, e-mail: ukhasanov@yahoo.com, tel: +998908082971;

U.N. Vokhidov, Department Otorinolaryngology, Tashkent State Dental Institute, Republic of Uzbekistan

Vokhidov Ulugbek Nuridinovich – DSc, associate professor of the Department Otorinolaryngology, Tashkent State Dental Institute, Republic of Uzbekistan, e-mail: dr_ulugbek@list.ru, tel: +998903454582;

J.A. Djuraev, Department of Otorinolarynology and Stomatology, Tashkent Medical Academy, Republic of Uzbekistan

Djuraev Jamolbek Abdukakharovich – DSc, associate professor of the Department of Otorinolarynology and Stomatology, Tashkent Medical Academy, Republic of Uzbekistan, e-mail: drdjuraev@mail.ru, tel: +998974000351.

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Published

2022-06-17

How to Cite

Khasanov, U., Vokhidov, U., & Djuraev, J. (2022). FREQUENCY OF IL 12B GENE POLYMORPHISM AMONG PATIENTS WITH CHRONIC RHINOSINUSITIS POLYPOSIS. JOURNAL OF EDUCATION AND SCIENTIFIC MEDICINE, 1(3), 54-58. Retrieved from https://journals.tma.uz/index.php/jesm/article/view/329

Issue

Vol. 1 No. 3 (2022)

Section

Articles