NEW EXPERIMENTAL MODEL OF PANCREONETCROSIS COMPLICATED WITH SEPSIS
Keywords:
pancreatic necrosis, pancreatogenic sepsis, experimental modeling, systemic inflammatory response syndrome, multiple organ dysfunctionAbstract
Background. Acute destructive pancreatitis remains one of the far from solved problems of modern urgent surgery. High mortality after pancreatic necrosis, especially when a generalized form of the inflammatory process develops, given the very high mortality rate, is today considered one of the most tragic situations in terms of the outcome of the disease. That is why any experimental research in the field of studying the pathogenesis of pancreatic necrosis complicated by sepsis today is considered relevant.
Metods. In order to model the optimal course of pancreatic necrosis complicated by sepsis, we studied 5 series of experiments on animals.
Results. As our studies and review of the issues discussed on this issue have shown, modeling of acute pancreatic necrosis, which could be complicated by sepsis, remains a far from solved problem of modern experimental surgery. When modeling acute pancreatic necrosis complicated by sepsis, along with the use of all pathogenetically significant factors, a separate link is required, which can radically affect the course of the general reactivity of the organism. Modeling of acute pancreatic necrosis complicated by sepsis is possible only under the condition of a combined approach of both local and general impact.
