MORPHOLOGY OF THE PANCREAS AGAINST THE BACKGROUND OF HYPOTHYROIDISM
Keywords:
mercazolil, pancreas, pancreatic lobesAbstract
Background. Hypothyroidism is associated with several disorders in all organs and systems due to the various effects of thyroid hormones. First, the circulatory system, the digestive system (liver function), the central nervous system, the organs of vision, and the reproductive system are affected.
Methods. Research has scientifically substantiated the results of inspections conducted on 56 white laboratory rats during early postnatal ontogenesis. In the complex morphological studies, which includes in its membership general histologic, histochemical techniques organometri, morphometry. Experiments and slaughter of animals were carried out by the “European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes”.
Results. The results of the study showed that the introduction of mercazolil into the lobes of the pancreas of experimental rats led to changes associated with the normalization of the structural organization of the pancreatic skull, interlobular connective tissue with the formation of fibrous tissue components, as well as the disappearance of choroid oedema observed in the interlobular connective tissue.
Conclusion. For the study, we used the offspring of rats born from control and experimental white laboratory rats - mothers under conditions of hypothyroidism. The results of the study showed that the introduction of Mercazolil into the pancreatic lobules of experimental rats led to changes associated with the normalization of the structural organization of the pancreatic cranium, interlobular connective tissue with the formation of fibrous tissue components, as well as the disappearance of choroidal oedema observed in the interlobular connective tissue.
References
Akhmedova S. M. Morphological characteristics of the development of the walls of the heart of rats // Science and the world. – 2015. – no. 1-2. - S. 85-87.
Cattail, William M. Pathophysiology of the endocrine system / William M. Cattail, A. Archy Ronald; per. from English. - M., 2009. - 336 p.
Karimov Kh., Akhmedova S., Ten S. Morphological characteristics of the development of the walls of the heart and their changes under the influence of pesticides // Journal Bulletin of the Doctor. - 2011. - T. 1. - No. 03. - S. 51-54.
Kurbanovich N. N. et al. Features Of Morphological Changes in the Pancreas // Texas Journal of Medical Science. - 2023. - T. 16. - S. 79-83.
Mirsharopov U. M., Akhmedova S. M. Influence of the hypothyrous state of the mother on the development of the organs and systems of the fetus // E Conference Zone. - 2022. - S. 25-28.
Mirsharopov U. M., Akhmedova S. M. Influence of maternal hypothyroidism on the development of fetal organs and systems // Conference Zone. - 2022. - S. 25-28.
Mukhamadovna A. S. et al. Indicators of Fetometry of the Fetus in Pregnant Women in a State of Hypothyroidism // Texas Journal of Medical Science. - 2023. - T. 16. - S. 75-78.
Niyazov N. K., Nabidjanova D., Valiyeva M. Indications of morphological changes of the pancreas in experimental hypothyroisis // International scientific conference "innovative trends in science, practice and education". - 2022. - Vol. 1. - No. 4. - S. 16-19.
Nadolnik, L. I. Features of the antioxidant status of the thyroid gland / L. I. Nadolnik, O. I.
Valentyukevich // Byul. experimental biology and medicine. - 2007. - No. 10. - S. 410-412.
Rakhimova M. O. et al. Fetometric indicators of fetuses in pregnant women in a state of hypothyroidism // Conference Organizing Committee. - 2021. - S. 143.
Sagatov T. A. et al. Morphological state of the microvasculature and tissue structures of the uterus in chronic intoxication with the pesticide "Vigor" // Problems of Science. – 2019. – no. 2 (38). - S. 56-60.
