PATHOGENETIC ASPECTS OF THE DEVELOPMENT OF DIABETIC FOOT SYNDROME

Abstract

At present, much has been achieved in the world in the field of treatment of diabetic foot syndrome, and multidisciplinary treatment approaches have been developed. However, despite all the achievements, the number of leg amputations in diabetes is growing. Every hour in the world, 55 patients with diabetes lose their lower limb, and in economically developed countries it varies from 13.7 to 32.3 per 100 100,000 population, which in turn is accompanied by a high mortality rate, costs for treatment and rehabilitation.  Studies have established that the course of the wound process is accompanied by a dynamic change of various biological reactions of the body, subject to the influence of many endogenous and exogenous factors that determine smooth wound healing or the development of various complications. One of the urgent problems today, which requires specialists to solve their solution, is developing immunopathogenetic mechanisms to increase the effectiveness of surgical and therapeutic measures in patients with diabetes mellitus complicated by diabetic foot syndrome, which occurs among the population of developed countries.