Abstract
Long-term non-healing wounds most often develop in patients with a burdened morbid background in the form of diabetes mellitus complicated by angio- and/or neuropathy, decompensated form of venous insufficiency, in bedridden patients for a long period. Long-term non-healing wounds are a health problem that has devastating consequences for patients and leads to serious costs for health systems and society. Unresolved problems in the treatment of long-term non-healing soft tissue wounds still account for the negative impact on the economy in any country in the world, regardless of its level of development.