GENERALIZATION OF INFECTION IN LONG-TERM NON-HEALING WOUNDS
Keywords:
long-term non-healing wounds, wound sepsis, systemic inflammatory response syndromeAbstract
Surgical sepsis must still be solved in the modern tanotogenetic statistical data structure. Sepsis against the background of the wound process, also known as wound sepsis, is considered the most common etiological cause of the development of this complication. Meanwhile, in the case of the development of wound infection, according to the literature, most authors pay attention to acute wounds, which, as is known, have a different pathogenetic mechanism of the course of the disease. However, in the context of the development and course of long-term non-healing wounds, there are few possible options for the generalization of infection in the literature. In this regard, our study aimed to identify the frequency of the development of clinical and laboratory signs of the systemic inflammatory response syndrome in patients with long-term non-healing wounds.
References
Trophic ulcers of the lower extremities - an overview of the problem. / V.N. Obolensky, G.V. Rodoman, V.G. Nikitin, M.A. Karev. // RMJ. 2019; 17:25(364):1647-1662. (in Russian)
Vasculitic and autoimmune wounds. / V.K. Shanmugam, D. Angra, H. Rahimi, S. McNish. // J. Vasc. Surg. Venous Lymphat Disord. 2017;5(2):280-292.
Tamrazova O.B. Long-term non-healing ulcers of the lower extremities: pathogenetic substantiation of the tactics of therapy choice: Diss... Dr. med. Sciences. Moscow, 2013. (in Russian)
Khramilin V.N. Modern aspects of local treatment of chronic wounds of the lower extremities in patients with diabetes mellitus. Scientific and Practical Medical Journal of ENC RAMS.2015;4:26-30. (in Russian)
Update on Sepsis and Septic Shock in Adult Patients: Management in the Emergency Department. / M. Guarino, B. Perna, A.E. Cesaro, et al. //J. Clin. Med. 2023 Apr 28;12(9):3188.
Cavaillon J.M., Singer M., Skirecki T. Sepsis Therapies: Learning from 30 Years of Failure of Translational Research to Propose New Leads. // EMBO Mol. Med.-2020;12:e10128.
Advances and Challenges in Sepsis Management: Modern Tools and Future Directions. / E. Santacroce, M. D'Angerio, A.L. Ciobanu, et al. // Cells.-2024;13(5):439.
Persistent Inflammation and Immunosuppression: A Common Syndrome and New Horizon for Surgical Intensive Care. / L.F. Gentile, A.G. Cuenca, P.A. Efron P.A., et al. // J. Trauma Acute Care Surg.-2012;72:1491–1501.
Bone R. Sir Isaac Newton, sepsis, SIRS and CARS // Crit. Care Med. 1996, vol. 24, #7 – P.1125–1127.
Bone R. The sepsis syndrome: Definition and general approach to management // Clinics in Chest Medicine, 1996, vol.17, #2 – P. 175–181.
Bone R. Why sepsis trials fail // JAMA, 1996, #276 – P.565–566.
Bone R., Balk R., Fein A. A second large controlled clinical study of E.S., a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized clinical trial // Crit. Care Med. 1995, # 23 – P. 994-1006.
Bone R., Grodzin Ch., Balk R. Sepsis: A New Hypothesis for Pathogenesis of the Disease Process. // Chest, 1997, vol. 112, # 1 – P.235–243.
Draft Resolution of the Conciliation Conference "Sepsis – Definition of the Concept, Issues of Terminology", Moscow, 13.10.98 // Surgery, 1999, No10-P.8-9. (in Russian)
Wu Y.K., Cheng N.C., Cheng C.M. Biofilms in chronic wounds: Pathogenesis and diagnosis. // Trends Biotechnol.-2019;37:505–517.
Local Immunomodulation using an adhesive hydrogel loaded with miRNA-laden nanoparticles promotes wound healing. / B. Saleh, H.K. Dhaliwal, R. Portillo-Lara, et al. // Small.-2019;15:e1902232.